In a game full of sadness like this, odd challenges are to be created throughout time.
These are the top 10 most unique challenges found in The Binding of Isaac Rebirth.
This does include spoilers for one or more ending bosses and scenes in the game Binding of Isaac Rebirth.
The main gimmick with his transformation is that you spawn friendly flies to do damage for you.
This challenge flips that over onto its head.
Brains is often considered to be one of the fairest unfair challenges in this game.
Blue Bomber
Unlike a few other challenges, this one finally makes you immune to explosions!
Unfortunately, its also your only way to attack in this challenge.
The Guardian
This challenge takes the form of almost every gamers worst nightmare, escort missions.
In this challenge you take the role of an invincible guardian angel for a friendly item named Punching Bag.
Sounds nice, except that there is a little heart that follows Punching Bag known as Isaacs Heart.
However, there are 2 scary mechanics in this run that are what makes it extra unique.
This is one run you absolutely need to become a penny pincher.
Aprils Fool
Aprils Fool is in an entirely different ball park when it comes to challenge.
The second part of this challenge that makes it so difficult comes to the boss.
This is alright when you usually fight him as a boss on the fifth or so floor.
The problem with this challenge is that the Bloat is the boss ofevery floor.
